Can i swap a U250E in to a camry 2.4 2002 ?

Can a I do this?

If you are asking if you can do it, I would say "no".

the transmission computer and the engine computer are interconnected and programmed to work together. Unless you have the skills to either rewire and/or reprogram to make something work I think it will just go into a default more.

why would you want to change the trans like this? Is there some advantage you thing you will get? Will it be worth the money? (and headache)